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0 0.5 1 1.5 2+ Mortality 33% Improvement Relative Risk Hospitalization 70% Symptomatic case 53% Case 50% c19bromhexine.com Tolouian et al. Bromhexine for COVID-19 RCT Prophylaxis Favors bromhexine Favors control
Tolouian, 372 patient bromhexine prophylaxis RCT: 70% lower hospitalization [p=0.15], 53% fewer symptomatic cases [p=0.007], and 50% fewer cases [p=0.03] https://c19p.org/tolouian2
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Bromhexine, for Post Exposure COVID-19 Prophylaxis: A Randomized, Double-Blind, Placebo Control Trial
Tolouian et al., SSRN, doi:10.2139/ssrn.3989 (Preprint)
20 Dec 2021    Source   PDF   Share   Tweet
PEP RCT with 372 close contacts of COVID+ patients, 187 treated with bromhexine, showing significantly lower cases with treatment. IRCT20120703010178N22.
Bromhexine may be less effective for omicron due to the entry process moving towards TMPRSS2-independent fusion.
risk of death, 32.9% lower, RR 0.67, p = 0.76, treatment 0 of 187 (0.0%), control 1 of 185 (0.5%), odds ratio converted to relative risk, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 70.3% lower, RR 0.30, p = 0.14, treatment 1 of 187 (0.5%), control 6 of 185 (3.2%), adjusted per study, odds ratio converted to relative risk.
risk of symptomatic case, 53.0% lower, RR 0.47, p = 0.007, treatment 16 of 187 (8.6%), control 34 of 185 (18.4%), NNT 10, odds ratio converted to relative risk.
risk of case, 50.2% lower, RR 0.50, p = 0.03, treatment 13 of 187 (7.0%), control 26 of 185 (14.1%), NNT 14, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tolouian et al., 12/20/2021, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, Middle East, preprint, 16 authors.
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