Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2

4/30 In Silico

Sgrignani et al., Frontiers in Molecular Biosciences, doi:10.3389/fmolb.2021.666626 (Peer Reviewed)
Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2

Source PDF Share Tweet

In SIlico study of TMPRSS2 inhibition by camostat, nafamostat, and bromhexine, suggesting allosteric binding for bromhexine, compared to camostat and nafamostat which bind to the active site of TMPRSS2 forming covalent adducts.

Sgrignani et al., 4/30/2021, peer-reviewed, 2 authors.

All 7 studies All Outcomes

Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.

Submit