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Bromhexine study #6   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hospitalization 80% Imp. Relative Risk, 95% CI Symptomatic case 91% Virological cure 71% Mikhaylov: Bromhexine Hydrochloride Prophylaxis of COVID-.. c19bromhexine.com/mikhaylov.html Favors bromhexine Favors control
3/8 Prophylaxis study
Mikhaylov et al., medRxiv, doi:10.1101/2021.03.03.21252855 (Preprint)
Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study
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Small prophylaxis RCT with 25 treatment and 25 control health care worker, showing lower PCR+, symptomatic cases, and hospitalization with treatment, although not statistically significant with the small sample size.
risk of hospitalization, 80.0% lower, RR 0.20, p = 0.49, treatment 0 of 25 (0.0%), control 2 of 25 (8.0%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of symptomatic case, 90.9% lower, RR 0.09, p = 0.05, treatment 0 of 25 (0.0%), control 5 of 25 (20.0%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of no virological cure, 71.4% lower, RR 0.29, p = 0.14, treatment 2 of 25 (8.0%), control 7 of 25 (28.0%).
Mikhaylov et al., 3/8/2021, Randomized Controlled Trial, Russia, Europe, preprint, 8 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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